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	Provedor de dados BJMBR (2) Autor Diniz,E.M.A. (2) Lyra,P.P.R. (2) Abe-Sandes,K. (1) Angelo,A.L.D. (1) Cardeal,M. (1) Hoffmann,J.W. (1) Machado,T.M.B. (1) Moreira,P.E. (1) Vaz,F.A.C. (1) de Mello,D.E. (1) Mais... Palavra-chave Surfactant protein B (2) Genetic polymorphism (1) Newborn respiratory distress syndrome (1) Polymorphisms (1) Respiratory distress syndrome (1) Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2011 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Comparison of surfactant protein B polymorphisms of healthy term newborns with preterm newborns having respiratory distress syndrome BJMBR Lyra,P.P.R.; Vaz,F.A.C.; Moreira,P.E.; Hoffmann,J.W.; de Mello,D.E.; Diniz,E.M.A.. Polymorphisms and mutations in the surfactant protein B (SP-B) gene have been associated with the pathogenesis of respiratory distress syndrome (RDS). The objective of the present study was to compare the frequencies of SP-B gene polymorphisms between preterm babies with RDS and healthy term newborns. We studied 50 preterm babies with RDS (inclusion criteria - newborns with RDS and gestational age between 28 and 33 weeks and 6 days), and 100 healthy term newborns. Four SP-B gene polymorphisms were analyzed: A/C at nucleotide -18, C/T at nucleotide 1580, A/G at nucleotide 9306, and G/C at nucleotide 8714, by PCR amplification of genomic DNA and genotyping by cRFLP. The healthy newborns comprised 42 female and 58 male neonates; 39 were white and 61... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polymorphisms; Surfactant protein B; Respiratory distress syndrome. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600005 Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome BJMBR Lyra,P.P.R.; Diniz,E.M.A.; Abe-Sandes,K.; Angelo,A.L.D.; Machado,T.M.B.; Cardeal,M.. The etiology of respiratory distress syndrome (RDS) is multifactorial and multigenic. Studies have suggested that polymorphisms and mutations in the surfactant protein B (SP-B) gene are associated with the pathogenesis of RDS. The objectives of this study were to determine and compare the frequencies of SP-B gene polymorphisms in preterm babies with and without RDS. We studied 151 neonates: 79 preterm babies without RDS and 72 preterm newborns with RDS. The following four SP-B gene polymorphisms were analyzed: A/C at -18, C/T at 1580, A/G at 9306, and G/C at nucleotide 8714. The polymorphisms were detected by PCR amplification of genomic DNA and genotyping. The genotypes were determined using PCR-based converted restriction fragment length polymorphisms.... Tipo: Info:eu-repo/semantics/other Palavras-chave: Newborn respiratory distress syndrome; Genetic polymorphism; Surfactant protein B. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000100010 Registros recuperados: 2 Primeira ... 1 ... Última

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